Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

WEE2

contributors: mct - updated : 17-05-2018

HGNC name	WEE1 homolog 2
HGNC id	19684

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function homozygous mutations in WEE2 are responsible for fertilization failure, decreased the amount of WEE2 protein and impaired the phosphorylation of both WEE2 and CDC2 leading to the failure of fertilization

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction fertility   potential therapeutic treatment in affected individuals by injecting WEE2 cRNA into her oocytes

ANIMAL & CELL MODELS