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FLASH GENE

Symbol

WEE2

contributors: mct - updated : 17-05-2018

HGNC name	WEE1 homolog 2
HGNC id	19684

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary     predominantly Homo sapiens   male system testis     moderately Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive oocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

WEE kinase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	is likely a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates
	responsible for phosphorylating the CDK1 inhibitory site and maintaining meiotic arrest in oocytes
	responsible for human fertilization failure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CAMK2A activates WEE2, and CAMK2A-driven exit from metaphase II is inhibited by WEE2 down-regulation
	WEE2 acts as a direct downstream substrate of protein kinase A (PRKACA)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function homozygous mutations in WEE2 are responsible for fertilization failure, decreased the amount of WEE2 protein and impaired the phosphorylation of both WEE2 and CDC2 leading to the failure of fertilization

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction fertility   potential therapeutic treatment in affected individuals by injecting WEE2 cRNA into her oocytes

ANIMAL & CELL MODELS