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FLASH GENE
Symbol MPZL3 contributors: mct - updated : 17-11-2017
HGNC name myelin protein zero like 3
HGNC id 27279
Location 11q23.3      Physical location : 118.100.336 - 118.123.011
DNA
TYPE functioning gene
STRUCTURE 25.68 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3950 - 223 - 2009 19054061
6 - 3986 - 235 - 2009 19054061
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two transmembrane motifs flanking an extracellular Ig-like domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • complex role for MPZL3 in the control of skin development, hair growth, and adipose cell functions
  • MPZL3 and FDXR increased reactive oxygen species (ROS) to drive epidermal differentiation
  • ROS induction by the MPZL3 and FDXR mitochondrial proteins is therefore essential for epidermal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in mitochondria, MPZL3 interacted with FDXR, which was itself also found to be essential for differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    caused a striking reduction in cutaneous and overall adipose tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • genetic ablation of Mpzl3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis
  • homozygous Mpzl3 knockout mice showed unkempt and greasy hair coat and hair loss soon after birth