basic FUNCTION
| putative intracellular tyrosine kinase adaptor protein |
|
likely involved in brain development |
|
activating tyrosine kinases |
|
intracellular adaptor that is tyrosine phosphorylated when RELN, a secreted glycoprotein, binds to the lipoprotein receptors VLDLR and ApoER2 on the surface of neurons |
|
involved in neuronal migration and lamination in the developing cerebral cortex |
|
resides within an unstable common site fragile region and might play a role in tumorigenesis |
|
key signaling molecule in the Reelin pathway that plays a critical role in neuronal migration and positioning during brain development 5) |
|
is required in radially migrating neurons for glia-independent somal translocation, but not for glia-guided locomotion |
|
mediates reelin signalling and plays critical roles in early brain development such as the stereotypical positioning of neurons in the brain |
|
may function as a tumor suppressor |
|
plays a key role in reelin-mediated neuronal migration during brain development |
|
adaptor protein that is an obligate effector of the RELN signaling pathway, and is critical for neuronal migration and dendrite outgrowth during development |
|
critical regulator of synaptic function and hippocampal-dependent associative and spatial learning |
|
DAB1 functions downstream of reelin action on the homeostasis of the crypt-villus unit |
|
possible involvements of RELN and DAB1 in the peripheral migrating stream |
|
plays a vital role in cytoskeleton, neuronal migration, and proliferation |