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FLASH GENE
Symbol LYAR contributors: mct - updated : 14-03-2017
HGNC name Ly1 antibody reactive
HGNC id 26021
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LYAR-type C2HC zinc finger motif
  • three nuclear localization signals
    • HOMOLOGY
    interspecies homolog to mouse Ly-1 antibody reactive clone
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • functions to control the stability of nucleolin protein, which in turn is essential for maintaining the self-renewal of ESCs
  • is strongly preferred in male germ cells, but has a dispensable role in spermatogenesis and fertility
  • accelerates ribosome biogenesis at the level of processing of preribosomal RNA (pre-rRNA)
  • is required for processing of 47S/45S, 32S, 30S and 21S pre-rRNAs
  • seems to be a new player in translational control
  • acts as a novel transcription factor that binds the gamma-globin gene, and is essential for silencing the gamma-globin gene
  • is a new ligand to stimulate RPE phagocytosis
  • key regulator of the migration and invasion of colorectal cancer (CRC) cells
  • LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in CRC
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacted with the methyltransferase PRMT5 which triggers the histone H4 Arg3 symmetric dimethylation (H4R3me2s) mark
  • LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of PDIA3, LYAR, NOP14, NCALD and MTSS1 genes in the ovarian cancer with poor prognosis
    tumoral     --over  
    in metastatic colorectal cancer (CRC) tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    male mutant mice lacking LYAR were fully fertile and showed intact spermatogenesis