Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LYAR contributors: mct - updated : 14-03-2017
HGNC name Ly1 antibody reactive
HGNC id 26021
Location 4p16.3      Physical location : 4.269.430 - 4.291.896
Synonym symbol(s) ZLYAR, ZC2HC2
DNA
TYPE functioning gene
STRUCTURE 22.47 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1584 - 379 - 2014 24990247
10 - 1486 - 379 - 2014 24990247
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Mus musculus
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LYAR-type C2HC zinc finger motif
  • three nuclear localization signals
    • HOMOLOGY
    interspecies homolog to mouse Ly-1 antibody reactive clone
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • functions to control the stability of nucleolin protein, which in turn is essential for maintaining the self-renewal of ESCs
  • is strongly preferred in male germ cells, but has a dispensable role in spermatogenesis and fertility
  • accelerates ribosome biogenesis at the level of processing of preribosomal RNA (pre-rRNA)
  • is required for processing of 47S/45S, 32S, 30S and 21S pre-rRNAs
  • seems to be a new player in translational control
  • acts as a novel transcription factor that binds the gamma-globin gene, and is essential for silencing the gamma-globin gene
  • is a new ligand to stimulate RPE phagocytosis
  • key regulator of the migration and invasion of colorectal cancer (CRC) cells
  • LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in CRC
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacted with the methyltransferase PRMT5 which triggers the histone H4 Arg3 symmetric dimethylation (H4R3me2s) mark
  • LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of PDIA3, LYAR, NOP14, NCALD and MTSS1 genes in the ovarian cancer with poor prognosis
    tumoral     --over  
    in metastatic colorectal cancer (CRC) tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    male mutant mice lacking LYAR were fully fertile and showed intact spermatogenesis