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FLASH GENE
Symbol NOTO contributors: mct - updated : 14-12-2016
HGNC name notochord homeobox
HGNC id 31839
DNA
TYPE functioning gene
STRUCTURE 8.95 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1448 - 251 - 2004 15231714
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • is required for caudal notochord development
  • NOTO regulates node morphogenesis and the posterior localization of cilia on node cells independently of FOXJ1
  • key regulators of motile ciliogenesis are the transcription factors FOXJ1 and NOTO, which are conserved throughout vertebrate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTO transcriptionally activates FOXJ1 expression and thus also regulates ciliogenesis
  • NOTO-dependent activation of FOXJ1 at the left/right organizer is crucial for proper determination of the left/right asymmetry, probably explaining situs anomalies in some FOXJ1 mutant individuals
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS