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FLASH GENE
Symbol CNBP contributors: mct/npt - updated : 24-10-2018
HGNC name CCHC-type zinc finger, nucleic acid binding protein
HGNC id 13164
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven zinc finger repeats
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • retroviral nucleic acid binding protein family
    • CATEGORY chaperone/stress , RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in sterol- mediated repression
  • with PCBP2, stimulate translation of the ornithine decarboxylase (ODC) internal ribosomal entry site (Gerbasi 2007)
  • appeared to function as part of a larger holo-ITAF ribonucleoprotein complex (Gerbasi 2007)
  • essential role in mediating neural crest expansion by controlling proliferation and cell survival rather than via a cell fate switch during rostral head development (Weiner 2007)
  • plays an essential and conserved role during vertebrate head development (Weiner 2007)
  • regulate cap-dependent and cap-independent translation (Huichalaf 2009)
  • is a nucleic acid chaperone implicated in vertebrate craniofacial development, as well as in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human muscle diseases
  • CNBP and LARP1, two of the most strongly enriched viral RNA binders, restrict SARS-CoV-2 replication in infected cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of an ITAF complex that promotes cap-independent translation (Gerbasi 2007)
    • INTERACTION
    DNA
    RNA RNA-binding protein
    small molecule
    protein
  • binding MBNL1
  • CNBP up-regulates TBX2 and SMARCA5, and down-regulates WNT5B gene expression
    • cell & other
  • cellular retroviral RNA binding
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DM2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS