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FLASH GENE
Symbol TMEM150B contributors: mct - updated : 08-12-2016
HGNC name transmembrane protein 150B
HGNC id 34415
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to DRAM1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,organelle,lysosome
text
  • localizes to lysosomes/autolysosomes, endosomes and the plasma membrane, but not the endoplasmic reticulum, phagophores, autophagosomes or Golgi, indicating significant overlap with DRAM1 localization and with organelles associated with macroautophagy
    • basic FUNCTION
  • modulator of both macroautophagy and cell survival under starvation conditions
  • autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1
  • like DRAM1, regulates both autophagy and cell death
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS