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FLASH GENE
Symbol TMEM150B contributors: mct - updated : 08-12-2016
HGNC name transmembrane protein 150B
HGNC id 34415
Location 19q13.42      Physical location : 55.824.226 - 55.836.708
Synonym name
  • tentonin 2
  • transmembrane protein 224
  • DRAM-Related/Associated Member 3
    • Synonym symbol(s) TMEM224, TTN2, DRAM3
    DNA
    TYPE functioning gene
    STRUCTURE 25.17 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 933 - 233 - 2016 27046253
    8 - 983 - 233 - 2016 27046253
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to DRAM1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • localizes to lysosomes/autolysosomes, endosomes and the plasma membrane, but not the endoplasmic reticulum, phagophores, autophagosomes or Golgi, indicating significant overlap with DRAM1 localization and with organelles associated with macroautophagy
    • basic FUNCTION
  • modulator of both macroautophagy and cell survival under starvation conditions
  • autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1
  • like DRAM1, regulates both autophagy and cell death
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS