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FLASH GENE
Symbol TMEM150C contributors: mct - updated : 07-12-2016
HGNC name transmembrane protein 150C
HGNC id 37263
Location 4q21.22      Physical location : 83.405.603 - 83.483.126
Synonym name
  • Tentonin3
    • Synonym symbol(s) TTN3
    DNA
    TYPE functioning gene
    STRUCTURE 77.52 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1888 - 249 - 2015 27321926
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • localized in muscle spindle afferents
    • basic FUNCTION
  • appears to be a component of a mechanosensitive channel with a slow inactivation rate and contributes to motor coordination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by mechanical stimuli with distinctly slow inactivation kinetics
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ttn3-deficient mice exhibited the loss of coordinated movements and abnormal gait