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FLASH GENE

Symbol

LHCGR

contributors: mct/npt - updated : 15-06-2017

HGNC name	luteinizing hormone/choriogonadotropin receptor
HGNC id	6585

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	68.97 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000233 11 splicing 3093 NP_000224 - 699 - 2016 27061682

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol endocrine gonadal cell Endocrine islet cell (alpha,beta...) Homo sapiens Endocrine thyroid cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N terminal extracellular domain containing nine leucine-rich repeat motifs
	a stretch of five amino acids Ala (A)-Phe (F)-Asn (N)-Gly (G)-Thr (T), highly conserved in glycoprotein hormone receptors
	a C terminal half homolog of the rhodopsin-like receptors

conjugated

GlycoP , PhosphoP

HOMOLOGY

interspecies	ortholog to murine Lhcgr
	homolog to Drosophila Fsh
	homolog to C.elegans C50H2.1

Homologene

FAMILY	G-protein coupled receptor 1 family
	FSH/LSH/TSH subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor)
	regulating in males the devopment and function of Leyding cells
	playing a role in male secondary sexual character development
	is a G(s)-coupled GPCR that is essential for the maturation and function of the ovary and testis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	development of Leyding cells

PATHWAY

metabolism

signaling

hormonal

a component	inactive mutant attenuates signaling of wild-type or constitutively active receptors via heterodimerization (Zhang 2009)
	coexpression of the LHCGR and FSHR enables heterodimerizaton between the 2 gonadotropin receptors and results in an attenuation of signaling through each receptor

INTERACTION

DNA

RNA

small molecule

protein	MVK binds to the coding region of LHCGR mRNA, suppresses its translation, and the resulting ribonucleoprotein complex is targeted for degradation
	ARF6 activated by the LHCGR through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling
	LHCGR signaling in regulating the AHR message involves protein kinase A pathway and is attributable to decreased transcription rate
	lack of the physiological down regulation of LHCGR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
	by inhibiting EIF5A hypusination, FSH reduces the expression of MVK that increases LHCGR mRNA expression by abrogating the inhibitory action of MVK

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PHLCH , PPML

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       secondary amenorrhea in females belonging to pedigrees of male patients with Leydig hypoplasia constitutional     --over   in granulosa cells (GC) from polycystic ovarian syndrome (PCOS) women constitutional germinal mutation       in empty follicle syndrome (EFS) in a family

Susceptibility

to endometrioid adenocarcinoma

Variant & Polymorphism SNP	rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS