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FLASH GENE
Symbol MYH8 contributors: mct/npt - updated : 12-05-2010
HGNC name myosin, heavy polypeptide 8, skeletal muscle, perinatal
HGNC id 7578
Corresponding disease
CNCTP Carney complex associated to trismus-pseudocamptodactyly
TPCS trismus-pseudocamptodactyly syndrome
Location 17p13.1      Physical location : 10.293.641 - 10.325.267
Synonym name
  • myosin heavy chain 8
  • fetal-myosin heavy chain
  • MyHC-perinatal
  • Synonym symbol(s) MyHC-pn, MyHC-peri, gtMHC-F
    DNA
    TYPE functioning gene
    STRUCTURE 31.63 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see MYH1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 6038 - 1937 - Jullian (1995)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal
    Text skeletal muscle, perinatal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • globular head associating to the light chain and containing actin and ATP binding sites
  • a neck containing IQ calmodulin or calmodulin-like light chain binding domain (the converter) connected to the base of a long alpha helical tail, (the liver)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text thick filaments of the myofibrils
    basic FUNCTION
  • motor contractile protein moving towards the "plus" end of actin track
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CNCTP , TPCS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS