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FLASH GENE
Symbol MID1IP1 contributors: mct - updated : 27-05-2015
HGNC name MID1 interacting protein 1
HGNC id 20715
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-zipper motif in its C-terminal region
    • HOMOLOGY
    intraspecies paralog to THRSP
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • both MID1IP1 and THRSP are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process
  • modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the first committed enzymatic reaction in the fatty acid synthesis pathway
  • is a mediator for stimulation of lipogenesis by NR1H2, NR1H3 activation in the liver
  • carbohydrate-inducible and thyroid-hormone-inducible nuclear protein specific to liver, adipose and lactating mammary tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • THRSP can form heterodimers with MID1IP1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to ACACA (ACACA is regulated at a tertiary level by MID1IP1, which facilitates ACACA polymerization and enhances enzymatic activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS