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FLASH GENE
Symbol MID1IP1 contributors: mct - updated : 27-05-2015
HGNC name MID1 interacting protein 1
HGNC id 20715
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
 stomach   highly Rattus norvegicus
Respiratorylung   highly Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-zipper motif in its C-terminal region
    • HOMOLOGY
    intraspecies paralog to THRSP
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • both MID1IP1 and THRSP are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process
  • modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the first committed enzymatic reaction in the fatty acid synthesis pathway
  • is a mediator for stimulation of lipogenesis by NR1H2, NR1H3 activation in the liver
  • carbohydrate-inducible and thyroid-hormone-inducible nuclear protein specific to liver, adipose and lactating mammary tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • THRSP can form heterodimers with MID1IP1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to ACACA (ACACA is regulated at a tertiary level by MID1IP1, which facilitates ACACA polymerization and enhances enzymatic activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS