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FLASH GENE

Symbol

MID1IP1

contributors: mct - updated : 27-05-2015

HGNC name	MID1 interacting protein 1
HGNC id	20715

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021242 3 - 3795 NP_067065 22 183 - 2010 2045793 NM_001098790 3 - 2020 NP_001092260 22 183 - 2010 2045793 NM_001098791 2 - 1916 NP_001092261 22 183 - 2010 2045793

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens   stomach       highly Rattus norvegicus Respiratory lung       highly Rattus norvegicus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a leucine-zipper motif in its C-terminal region

HOMOLOGY

intraspecies

paralog to THRSP

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus

basic FUNCTION	both MID1IP1 and THRSP are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process
	modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the first committed enzymatic reaction in the fatty acid synthesis pathway
	is a mediator for stimulation of lipogenesis by NR1H2, NR1H3 activation in the liver
	carbohydrate-inducible and thyroid-hormone-inducible nuclear protein specific to liver, adipose and lactating mammary tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

THRSP can form heterodimers with MID1IP1

INTERACTION

DNA

RNA

small molecule

protein

binds to ACACA (ACACA is regulated at a tertiary level by MID1IP1, which facilitates ACACA polymerization and enhances enzymatic activity)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS