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FLASH GENE
Symbol MID1IP1 contributors: mct - updated : 27-05-2015
HGNC name MID1 interacting protein 1
HGNC id 20715
Location Xp11.4      Physical location : 38.660.684 - 38.665.781
Synonym name
  • gastrulation specific G12 homolog
  • spot 14-R
  • spot 14-related protein
  • Spot 14-like androgen-inducible protein
    • Synonym symbol(s) G12-like, MIG12, S14R, STRAIT11499, THRSPL, slap
    DNA
    TYPE functioning gene
    STRUCTURE 5.10 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3795 22 183 - 2010 2045793
    3 - 2020 22 183 - 2010 2045793
    2 - 1916 22 183 - 2010 2045793
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
     stomach   highly Rattus norvegicus
    Respiratorylung   highly Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine-zipper motif in its C-terminal region
    • HOMOLOGY
    intraspecies paralog to THRSP
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • both MID1IP1 and THRSP are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process
  • modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the first committed enzymatic reaction in the fatty acid synthesis pathway
  • is a mediator for stimulation of lipogenesis by NR1H2, NR1H3 activation in the liver
  • carbohydrate-inducible and thyroid-hormone-inducible nuclear protein specific to liver, adipose and lactating mammary tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • THRSP can form heterodimers with MID1IP1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to ACACA (ACACA is regulated at a tertiary level by MID1IP1, which facilitates ACACA polymerization and enhances enzymatic activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS