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FLASH GENE
Symbol WDR73 contributors: mct - updated : 07-01-2016
HGNC name WD repeat domain 73
HGNC id 25928
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD40 motifs
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • diffuse in the cytosol during interphase and enriched at the spindle poles and microtubule asters during mitosis
    • basic FUNCTION
  • WD40-repeat-containing protein, cell-cycle dependent
  • crucial role for WDR73 in the regulation of microtubule dynamics and organization during interphase
  • potential role for WDR73 in cell survival and microtubule regulation
  • potentially playing a crucial role in the development and maturation of the nervous system and in the maintenance of the proper function and integrity of glomerular filtration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GAMOS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS