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FLASH GENE

Symbol

WDR73

contributors: mct - updated : 07-01-2016

HGNC name	WD repeat domain 73
HGNC id	25928

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GAMOS1 Galloway-Mowat syndrome
Location	15q25.2      Physical location : 85.186.011 - 85.197.521
Synonym symbol(s)	HSPC264

DNA

TYPE	functioning gene
STRUCTURE	11.91 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032856 8 - 1855 NP_116245 - 378 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum     Homo sapiens Urinary kidney         Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Urinary podocyte Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six WD40 motifs

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	diffuse in the cytosol during interphase and enriched at the spindle poles and microtubule asters during mitosis

basic FUNCTION	WD40-repeat-containing protein, cell-cycle dependent
	crucial role for WDR73 in the regulation of microtubule dynamics and organization during interphase
	potential role for WDR73 in cell survival and microtubule regulation
	potentially playing a crucial role in the development and maturation of the nervous system and in the maintenance of the proper function and integrity of glomerular filtration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GAMOS1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS