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FLASH GENE
Symbol ANGPTL8 contributors: mct - updated : 22-08-2016
HGNC name angiopoietin like 8
HGNC id 24933
Location 19p13.2      Physical location : -
Synonym name
  • betatrophin
  • lipasin
  • betatrophin variant 1
  • chromosome 19 open reading frame 80
  • betatrophin variant 2
  • angiopoietin-like protein 8
    • Synonym symbol(s) RIFL, TD26, C19orf80, PRO1185, PVPA599, Gm6484
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text located in the corresponding intron of DOCK6
    STRUCTURE 2.32 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 888 - 198 - 2013 2326144
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposebrown highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lack of C-terminal fibrinogen-like domain
    • HOMOLOGY
    intraspecies homolog to homologous to ANGPTL3’s N-terminal regions that mediate serum triglyceride regulation
    paralog to ANGPTL3
    Homologene
    FAMILY ANGPTL family
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism
  • ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs
  • regulates serum triglycerides
  • lipasin and some ANGPTLs play distinct physiological roles in mediating thermogenesis and energy homeostasis
  • regulate blood lipid profiles at different nutritional states
  • circulating factor that regulates lipid metabolism and promotes pancreatic beta-cell proliferation
  • is nutritionally-regulated hepatokine that is increased in human type 2 diabetes and obesity
  • feeding-induced hepatokine that regulates triglyceride (TAG) metabolism
  • play a role in insulin resistance and beta-cell proliferation
  • ANGPTL8 may function as an important metabolic switch, by forming complexes with ANGPTL3, or with ANGPTL4, in order to direct the flow of energy from triglycerides in blood according to the needs of the body
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • T 3 regulates lipid metabolism through a C19orf80-activated autophagic process
  • ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3
  • ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in the presence of ANGPTL3
  • ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL
    • cell & other
    REGULATION
    activated by by T 3 (T 3 stimulation led to upregulation of both mRNA and protein levels of C19orf80)
    induced by high-fat diet treatment that increases Lipasin
    cold exposure that increases Lipasin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in subjects with metabolic syndrome and it was significantly associated with high sensitivity C-reactive protein (HsCRP) levels in different subgroups highlighting its potential role in metabolic and inflammatory pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    metabolismlipid 
    inhibition of ANGPTL8 provides a new therapeutic strategy for reducing plasma lipoprotein levels
    ANIMAL & CELL MODELS
  • Lipasin-deficient mice exhibited elevated postprandial activity of LPL in the heart and skeletal muscle, but not in white adipose tissue (WAT), suggesting that lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles