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FLASH GENE

Symbol

BCR

contributors: mct/npt - updated : 21-05-2017

HGNC name	breakpoint cluster region
HGNC id	1014

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BCR-ABL , DEL22Q11D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       BCR-JAK2 fusion result of a t(9;22)(p24;q11.2) translocation in chronic myeloid leukemia tumoral fusion       fused with FGFR1 in t(8;22) (p11;q11) in myelo proliferative disorder and with PDGFRA in t(4;22) (q12;q11) in atypical chronic myeloid leukemia tumoral fusion       with ABL1, in reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   BCR/DDX39B interaction may be a target for inhibiting pathological VSMC proliferation cancer hemopathy   targeting ROR1 simultaneously with inhibition of B-cell receptor (BCR) signaling is more effective in killing ROR1-positive leukemia cells

ANIMAL & CELL MODELS