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FLASH GENE
Symbol PIK3R5 contributors: mct - updated : 10-02-2014
HGNC name phosphoinositide-3-kinase, regulatory subunit 5
HGNC id 30035
Location 17p13.1      Physical location : 8.782.233 - 8.869.024
Synonym name
  • PI3-kinase p101 subunit
  • phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
  • Synonym symbol(s) p101, FOAP-2, P101-PI3K, F730038I15Rik
    DNA
    TYPE functioning gene
    STRUCTURE 86.80 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4368 - 494 - 2003 12507995
    18 - 4389 - 494 - 2003 12507995
    19 - 4543 101 880 - 2003 12507995
    19 - 4605 - 494 - 2003 12507995
    19 - 4449 101 880 - 2003 12507995
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PIK3R6
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • required for G protein-mediated activation of PIK3CG in living cells
  • its overexpression ctivates PI3Kgamma signaling in T cells and contributes to cell survival (
  • differential functions of the two PIK3CG regulatory subunits PIK3R5, and PIK3R6 in the process of oncogenesis
  • may play a role in the development of the cerebellum and vermis
  • non-catalytic subunit assumed to be redundant adaptors for GNB1/GNGT1 enabling G-protein-coupled receptor-mediated regulation of PI3Kgamma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of phosphatidylinositol-3-kinase-gamma (PI3Kgamma)
  • PIK3CG has two potential regulatory subunits PIK3R5, PIK3R6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • like PIK3R5, PIK3R6 binds to both PIK3CG and Gbetagamma and mediates activation of PIK3CG downstream of G protein-coupled receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS