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FLASH GENE
Symbol PPM1K contributors: mct - updated : 17-12-2013
HGNC name protein phosphatase, Mg2+/Mn2+ dependent, 1K
HGNC id 25415
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved organization of PP2C phosphatases
  • presence of two bound metal ions in the active site
    • secondary structure
  • structure dominated by two central beta-sheets that pack on each other, forming a beta-sandwich; flanking each beta-sheet is a pair of antiparallel alpha-helices
    • HOMOLOGY
    Homologene
    FAMILY PPM family of Mn2+/Mg2+-dependent phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • mitochondria-targeted protein phosphatase,that is the branched-chain alpha-keto dehydrogenase (BCKD)phosphatase and thus serves as a key regulator for Branched-chain amino acid (BCAA) catabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • competes with the BCKD kinase (BCKDK) in a substrate-dependent and mutually exclusive manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MSUDMV
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS