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FLASH GENE
Symbol PPM1K contributors: mct - updated : 17-12-2013
HGNC name protein phosphatase, Mg2+/Mn2+ dependent, 1K
HGNC id 25415
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveliver   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Respiratorydiaphragm   highly Homo sapiens
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved organization of PP2C phosphatases
  • presence of two bound metal ions in the active site
    • secondary structure
  • structure dominated by two central beta-sheets that pack on each other, forming a beta-sandwich; flanking each beta-sheet is a pair of antiparallel alpha-helices
    • HOMOLOGY
    Homologene
    FAMILY PPM family of Mn2+/Mg2+-dependent phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • mitochondria-targeted protein phosphatase,that is the branched-chain alpha-keto dehydrogenase (BCKD)phosphatase and thus serves as a key regulator for Branched-chain amino acid (BCAA) catabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • competes with the BCKD kinase (BCKDK) in a substrate-dependent and mutually exclusive manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MSUDMV
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS