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FLASH GENE
Symbol PRAP1 contributors: mct - updated : 07-12-2001
HGNC name proline-rich acidic protein 1
HGNC id 23304
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may play an important role in maintaining normal growth homeostasis in epithelial cells
  • appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of PRAP1 expression by TP53 in response to DNA-damaging agents contributes to cancer cell survival
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRAP1 is a novel TP53 target gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma and right colon adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS