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FLASH GENE
Symbol PRAP1 contributors: mct - updated : 07-12-2001
HGNC name proline-rich acidic protein 1
HGNC id 23304
DNA
TYPE functioning gene
STRUCTURE 17.83 kb     5 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • functional TP53-response elements within intron 1 of PRAP1 gene
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 780 - 141 - 2003 14583459
    5 - 807 - 151 - 2003 14583459
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play an important role in maintaining normal growth homeostasis in epithelial cells
  • appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of PRAP1 expression by TP53 in response to DNA-damaging agents contributes to cancer cell survival
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRAP1 is a novel TP53 target gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma and right colon adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS