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FLASH GENE
Symbol PCGF1 contributors: mct - updated : 04-11-2013
HGNC name Polycomb-group RING finger
HGNC id 17615
Location 2p12      Physical location : 74.732.177 - 74.734.821
Synonym name
  • Nervous system polycomb 1
    • Synonym symbol(s) RNF68, NSPC1, RNF3A-2
    DNA
    TYPE functioning gene
    STRUCTURE 3.54 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 939 - 259 - 2006 17088287
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger- and WD40-associated ubiquitin-like (RAWUL) domain
  • both the C-terminal of NSPC1 and two phosphorylation sites in the C-terminal, especially the PKC phosphorylation site at S183, were important in mediating transcription repression
    • HOMOLOGY
    Homologene
    FAMILY PcG family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • localized mainly in the nucleus
    • basic FUNCTION
  • has powerful transcriptional repression ability, which may be related to the PKC signaling pathway
  • could promote tumor cell cycle progression and cell proliferation
  • is an epigenetic regulator involved in hematopoietic cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • has a positive role in tumor cell growth by down-regulating CDKN1A via the RARE element, which directly connects transcriptional repression of PcGs to CDKIs and RA signaling pathways
  • concerted action of the transcription factor RUNX1, together with the epigenetic repressor PCGF1, is necessary for terminal differentiation
  • BCOR binds the RING finger- and WD40-associated ubiquitin-like (RAWUL) domain of PCGF1 (NSPC1) and PCGF3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS