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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

AFP

contributors: mct - updated : 12-07-2015

HGNC name	alpha-fetoprotein
HGNC id	317

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

AFP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function differentially upregulated in yolk sac tumors of germ cells tumoral     --over   in the majority of hepatocellular carcinomas constitutional     --over   in ASD (autism spectrum disorders)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	AFP is a good candidate for further larger-scale studies to confirm such an association and to determine whether this pattern is unique to ASD or related to other psychiatric disorders as well
	low AFP levels and increased CA 19-9 levels can be used as tumor markers in diagnosis of molar pregnancies in conjunction with clinical and sonographic findings and serum levels of HCG
Therapy target

ANIMAL & CELL MODELS