basic FUNCTION
| PGAP1 encoded an ER-associated, 922-amino acid membrane protein bearing a lipase consensus motif, that is the GPI inositol-deacylase |
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the remodeling requires the preceding PGAP1-mediated deacylation from inositol of GPI-APs in the endoplasmic reticulum |
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PGAP1 is a deacylase that removes an acyl-chain from the inositol of GPI anchors in the endoplasmic reticulum immediately after attachment of GPI to proteins |
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protein localized in the endoplasmic reticulum responsible for the first step of the remodeling of glycosylphosphatidylinositol |
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soon after GPI is attached, an acyl chain on the GPI inositol is removed by post-GPI attachment to proteins 1 (PGAP1), a GPI-inositol deacylase |