Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZNF668

contributors: mct - updated : 06-04-2013

HGNC name	zinc finger protein 668
HGNC id	25821

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	nucleolar protein that physically interacts with and regulates TP53 and its negative regulator MDM2
	novel breast tumor suppressor gene that functions in regulating TP53 stability

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

through MDM2 binding, ZNF668 regulated autoubiquitination of MDM2 and its ability to mediate TP53 ubiquitination and degradation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS