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FLASH GENE
Symbol ZNF668 contributors: mct - updated : 06-04-2013
HGNC name zinc finger protein 668
HGNC id 25821
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • nucleolar protein that physically interacts with and regulates TP53 and its negative regulator MDM2
  • novel breast tumor suppressor gene that functions in regulating TP53 stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • through MDM2 binding, ZNF668 regulated autoubiquitination of MDM2 and its ability to mediate TP53 ubiquitination and degradation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS