| basic FUNCTION
| major photoreceptor protein involved in desensitization of thephosphoactivated transduction cascade |
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binding to phosphoactivated-phosphorylated rhodopsin, apparently preventing the transducin-mediated activation of phosphodiesterase |
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inducing BDR1 (CXCR5) and CXCR3 to migrate |
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capable of inducing experimental autoimmune uveoretinitis |
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higly antigenic |
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essential for cone photoreceptor survival, light adaptation and for maintaining normal flicker responses (Brown et al, 2010) |
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protects cones from light-independent dystrophy (Brown et al, 2010) |
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maintenance of low levels of the active monomer is the biological role of SAG self-association  |
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monomeric SAG is cytotoxic and WT SAG protects rods by forming mixed oligomers with the mutant and/or competing with it for the binding to non-receptor partners |
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plays a key role in the rapid recovery of the light response |
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light-induced SAG translocation from the inner segment to the outer segment, is a process that may be protective against cellular damage incurred by constitutive signaling |
