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FLASH GENE
Symbol CD28 contributors: mct/ - updated : 30-06-2017
HGNC name CD28 molecule
HGNC id 1653
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • immunoglobulin V type and C type domain
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Cd28
    intraspecies homolog to NADH ubiquinone oxidoreductase
    Homologene
    FAMILY
  • inducible costimulator family (CD28 gene family)
    • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating PDE7 for T cell activation and required for the formation of the mature immunologic synapse
  • CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of costimulatory signal, with B7-1 (MIC17/CD80) and BF-2 (CD86)
  • homodimer disulfide-linked
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD80, CD86 ligand, PRKCQ (within the immunologic synapse)
  • HNRNPLL expression is dependent on CD28 signaling, providing a mechanism by which CD28 can regulate splicing in T cells and insight into how HNRNPLL can influence signal-induced alternative splicing in T cells
  • enforces a requirement for CD28 costimulation by limiting IL2 production
  • CARMIL2 is essential for CD28 co-stimulation in human T cells
    • cell & other
    REGULATION
    Other regulated by CBLB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to celiac disease
  • to unexplained pregnancy loss
    • Variant & Polymorphism other imbalance in CTLA4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS