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FLASH GENE

Symbol

CD28

contributors: mct/ - updated : 30-06-2017

HGNC name	CD28 molecule
HGNC id	1653

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	31.36 kb     4 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   enhancer
text structure	promoter element CD28GR in exon1 with Sp1/ EGR1binding sites conferring transcriptional activation

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006139 4 - 3807 NP_006130 25.1 220 - 1987 2825196

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Lymphoid/Immune thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

immunoglobulin V type and C type domain

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Cd28

intraspecies

homolog to NADH ubiquinone oxidoreductase

Homologene

FAMILY

inducible costimulator family (CD28 gene family)

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	stimulating PDE7 for T cell activation and required for the formation of the mature immunologic synapse
	CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of costimulatory signal, with B7-1 (MIC17/CD80) and BF-2 (CD86)
	homodimer disulfide-linked
	CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival

INTERACTION

DNA

RNA

small molecule

protein	CD80, CD86 ligand, PRKCQ (within the immunologic synapse)
	HNRNPLL expression is dependent on CD28 signaling, providing a mechanism by which CD28 can regulate splicing in T cells and insight into how HNRNPLL can influence signal-induced alternative splicing in T cells
	enforces a requirement for CD28 costimulation by limiting IL2 production
	CARMIL2 is essential for CD28 co-stimulation in human T cells

cell & other

REGULATION

Other

regulated by CBLB

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to celiac disease to unexplained pregnancy loss

Variant & Polymorphism other	imbalance in CTLA4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS