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FLASH GENE
Symbol VPS37A contributors: shn - updated : 14-11-2015
HGNC name vacuolar protein sorting 37 homolog A (S. cerevisiae)
HGNC id 24928
Corresponding disease
SPG53 early-onset complex autosomal recessive spastic paraplegia-53
Location 8p22      Physical location : 17.104.400 - 17.155.532
Synonym name
  • polyglutamine binding protein 2
  • vacuolar protein sorting 37A (yeast)
  • hepatocellular carcinoma related protein 1
  • hepatocellular carcinoma-related protein 1
  • ESCRT-I complex subunit VPS37A
  • vacuolar protein sorting 37A
  • vacuolar protein sorting-associated protein 37A
    • Synonym symbol(s) FLJ32642, HCRP1, PQBP2, SPG53, hVps37A
    DNA
    TYPE functioning gene
    STRUCTURE 51.13 kb     11 Exon(s)
    MAPPING cloned   linked   status confirmed
    Map pter - D8S549 - D8S254 - VPS37A - D8S261 - D8S1715 - cen
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 4510 - 372 - -
    11 splicing 4585 - 397 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiensNM_152415
    Digestiveliver   highly Homo sapiensNM_152415
    Endocrinepancreas   moderately Homo sapiensNM_152415
    Nervousbrain   moderately Homo sapiensNM_152415
    Reproductivefemale systemplacenta  moderately Homo sapiensNM_152415
    Respiratorylung   moderately Homo sapiensNM_152415
    Urinarykidney   moderately Homo sapiensNM_152415
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately Homo sapiensNM_152415
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a mod(r) domain
    • HOMOLOGY
    interspecies ortholog to Vps37a, mus musculus
    ortholog to Vps37a, Rattus norvegicus
    ortholog to vps37a, Danio rerio
    homolog to Vps37, yeast
    Homologene
    FAMILY
  • Helix contactin-related proteins
    • CATEGORY
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm
    intracellular,nucleus
    text diffused in the cytoplasm with a significant fraction accumulated in the nuclei
    basic FUNCTION
  • might be a growth inhibitory protein and associated with decreasing the invasion of hepatocellular carcinoma cells
  • essential for lysosomal sorting of EGF receptors and required for downregulation of the epidermal growth
    • factor receptor via degradation
  • an independent predictor for postoperative disease-free survival in hepatocellular carcinoma patients
  • a possible novel predictive marker for ovarian cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a subunit of the ESCRT-I complex
  • presence of UBAP1, in combination with VPS37A, defines an endosome-specific ESCRT-I comple
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSG101
  • Tsg101 and hVps28
  • UBAP1
  • UBAP1, a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with TSG101, VPS28, and VPS37A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG53
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS
  • overexpression of HCRP1 (Vps37A) significantly inhibited both anchorage-dependent and anchorage-independent cell growth in vitro
  • knock down of the expression of HCRP1 gene by shRNA in hepatocellular carcinoma cell line BEL-7404 result in the cell growth greatly enhanced
  • Vps37A morpholino-injected zebrafish showed striking and significant loss of motility