| basic FUNCTION
| regulates the proliferation of U937 cell through CDKN1B-RB signaling pathway, which may be important for the pathogenesis of leukemia  |
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enzymatic activity of POGLUT1 is key to its regulatory role in the Notch pathway |
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is likely to have additional important targets during mammalian development |
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soluble, endoplasmic reticulum-retained protein that functions as a protein O-glucosyltransferase |
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catalyze transfer of glucose from UDP-glucose to an EGF repeat from human factor VII |
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primarily regulates Notch signaling through its enzymatic activity, and regulation of Notch signaling by PGLUT1 depends potentially on the addition of O-glucose or O-Xyl to Notch pathway components by POGLUT1 |
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enhanced Notch activation |
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having protein O-xylosyltransferase activity |
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POGLUT1 and POFUT1 are essential regulators of Notch activity |
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important for the correct differentiation of the epidermal layer and might emphasize an important role for POGLUT1 in the development of the epidermis |
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is a protein-O-glucosyltransferase that transfers glucose and xylose to the EGF-like domains of Notch and other signaling receptors |
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Poglut1 contributes to myogenesis by regulating Notch signaling and defining, directly or indirectly, the proportion of cells that commit differentiation |
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POGLUT1, POGLUT2, POGLUT3, use uridine diphosphate (UDP)-Glc as a substrate to modify EGF repeats and reside in the endoplasmic reticulum via C-terminal KDEL-like signals, and in addition to O-glucosylation activity, POGLUTs can also perform protein O-xylosylation function |
