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FLASH GENE

Symbol

VGLL4

contributors: mct - updated : 06-01-2021

HGNC name	vestigial like 4 (Drosophila)
HGNC id	28966

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014667 6 - 3725 NP_055482 - 290 - 2011 21839727 NM_001128219 5 - 3783 NP_001121691 - 296 - 2011 21839727 NM_001128220 4 - 3182 NP_001121692 - 210 - 2011 21839727 NM_001128221 4 - 3425 NP_001121693 - 206 - 2011 21839727 NM_001284390 7 - 3652 NP_001271319 - 295 - 2011 21839727 NM_001284391 5 - 3562 NP_001271320 - 231 - 2011 21839727

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two TDU motifs , two tandem TDU motifs, suggesting that VGLL4 has distinct molecular functions among this family

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus
text	expressed predominantly in the nucleus

basic FUNCTION	modulates the activity of TEAD1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes)
	functions as a transcription cofactor in cardiac myocytes
	may play a role in the apoptotic pathways by regulating translocation of BIRC2, BIRC3 and XIAP between different cell compartments
	could antagonize the anti-apoptotic activity of BIRC2, BIRC3 and XIAP by sequestering IAPs in nucleus
	VGLL4 is a novel regulator of survival in human embryonic stem cells
	is a novel tumor suppressor for lung cancer through negatively regulating the YAP1-TEAD complex formation and thus the Hippo pathway
	acetylation-mediated, VGLL4-dependent switch that regulates TEAD stability and YAP1-TEAD activity
	VGLL4 is a transcriptional repressor that interacts with transcription factors TEADs and inhibits YAP1-induced overgrowth and tumorigenesis
	USP11 controls VGLL4 protein stability by promoting its deubiquitination
	VGLL4 is a candidate tumor suppressor gene which acts by selectively antagonizing YAP1-dependent tumor growth
	VGLL4 is found to play an important role in several signal pathways, mainly acts as a tumor suppressor interacting with TEADs, and can also suppress epithelial-mesenchymal transition (EMT) and contribute to apoptosis signaling pathway
	VGLL4 is important for valve development
	VGLL4 plays an important role in regulating osteoblast differentiation and bone development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

TEAD4-VGLL4-CTBP2 ternary complex dynamically existed at the early stage of adipogenesis

INTERACTION

DNA

RNA

small molecule

protein	BIRC2, BIRC3 and XIAP binding protein
	negatively regulates the TEAD1-YAP1 transcriptional complex and exerts its growth inhibitory control through its evolutionary conserved TDU2 domain at its C-terminus
	functions as a transcriptional co-repressor in the Hippo-Yes-associated protein (YAP1) pathway
	VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CTBP2
	VGLL4 is an important regulator of CD274 expression, suggesting a central role of VGLL4 and YAP1 in the regulation of tumor immunity

cell & other

REGULATION

Phosphorylated by

CDK1 (phosphorylated CDK1 during antimitotic drug-induced mitotic arrest and also in normal mitosis)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   was very important in the progression of esophageal squamous cell carcinoma (ESCC) tumoral     --over   reduces breast cancer cell proliferation, migration, intravasation/extravasation potential, favors cell death, and suppresses tumor growth

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive oesophagus restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC cancer reproductive breast may be a promising therapeutic target in breast cancer

ANIMAL & CELL MODELS