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FLASH GENE
Symbol PDHB contributors: mct/npt - updated : 29-04-2013
HGNC name pyruvate dehydrogenase (lipoamide) beta
HGNC id 8808
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • catalyzing the overall conversion of pyruvate to acetyl-Coa
  • involved in tricarboxylic acid cycle, glucose metabolism
  • involved in fatty acid oxidation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • E1 beta subunit of the complex forming an heterotetramer alpha2beta2 bound to two TPP (thiamine-pyrophosphate) one each bridging E1 alpha and E1 beta to form an active site catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • thiamine pyrophosphate
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PDHB
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS