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FLASH GENE
Symbol PIGG contributors: mct - updated : 14-04-2016
HGNC name phosphatidylinositol glycan anchor biosynthesis, class G
HGNC id 25985
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to yeast Gp17
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • involved in adding ethanolaminephosphate to the second mannose in the biosynthesis of glycosylphosphatidylinositol (GPI)
  • enzyme that modifies the second mannose with ethanolamine phosphate, which is removed soon after GPI is attached to the protein
  • attaches ethanolamine phosphate (EtNP) to the second mannose. Different from other PIG genes, PIGG is not essential for GPI-AP biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • GPI-biosynthesis pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • second partner of PIGF and involved in modification of glycosylphosphatidylinositol
  • competition between the two independent enzymes, PIGO and PIGG, for the common stabilizer, PIGF
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PIGGD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS