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FLASH GENE
Symbol PIGG contributors: mct - updated : 14-04-2016
HGNC name phosphatidylinositol glycan anchor biosynthesis, class G
HGNC id 25985
Corresponding disease
PIGGD PIGG deficiency
Location 4p16.3      Physical location : 492.988 - 533.319
Synonym name
  • GPI ethanolamine phosphate transferase 2
  • GPI7 homolog
    • Synonym symbol(s) UNQ1930/PRO4405, GPI7, LAS21, PRO4405, RLGS1930
    DNA
    TYPE functioning gene
    STRUCTURE 40.72 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3266 - 983 - 2005 15632136
    13 - 3242 - 975 - 2005 15632136
    11 - 3241 - 850 - -
    13 - 3449 - 894 - -
    7 - 2685 - 299 - -
    9 - 2691 - 341 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast Gp17
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in adding ethanolaminephosphate to the second mannose in the biosynthesis of glycosylphosphatidylinositol (GPI)
  • enzyme that modifies the second mannose with ethanolamine phosphate, which is removed soon after GPI is attached to the protein
  • attaches ethanolamine phosphate (EtNP) to the second mannose. Different from other PIG genes, PIGG is not essential for GPI-AP biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • GPI-biosynthesis pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • second partner of PIGF and involved in modification of glycosylphosphatidylinositol
  • competition between the two independent enzymes, PIGO and PIGG, for the common stabilizer, PIGF
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PIGGD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS