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FLASH GENE

Symbol

GRK4

contributors: mct/npt - updated : 10-11-2014

HGNC name	G protein-coupled receptor kinase 4
HGNC id	4543

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta     highly Homo sapiens Nervous nerve cranial nerve     highly Reproductive male system testis     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth vessel     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RGS domain
	a protein kinase domain

HOMOLOGY

interspecies	homolog to Drosophila G protein coupled receptor kinase 2
	ortholog to murine Gprk2l

Homologene

FAMILY	G protein coupled receptor family
	Ser/Thr family of protein kinases
	GPRK subfamily

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	associate with the cell membrane through palmitoylation of the cysteine residue at its C terminus
	both DRD3 and GRK4 co-localize in lipid rafts of human renal proximal tubule cells (Villar 2009)

basic FUNCTION	inhibiting the dopamine receptor D1 (DRD1) from increasing sodium excretion
	mediating the pressure and natriuresis relation
	involved in renal sodium handling and blood pressure regulation (Hasenkamp 2008)
	required for DRD3-mediated mitogenesis and activation of the MAP kinase pathway inrenal proximal tubule cells (Villar 2009)
	via regulation of arterial AGTR1 expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction between DRD3 and GRK4 (Villar 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to essential hypertension

Variant & Polymorphism other	variant in isoform GRK4 gamma associated with essential hypertension
	65L allele is associated with stress-induced urinary sodium excretion reduction, suggesting impaired sodium handling in black normotensive adolescents

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS