Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL10RB contributors: mct - updated : 22-11-2012
HGNC name interleukin 10 receptor, beta
HGNC id 5965
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type-III domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Il10rb
    homolog to chicken il10rb
    Homologene
    FAMILY
  • type II cytokine receptor family
    • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to membrane
  • type I membrane protein
    • basic FUNCTION
  • acting as a receptor for IL10 and IL22
  • serving as an accessory chain essential for the active IL10 receptor complex and to initiate IL10-induced signal transduction events
  • IL20RA and IL10RB chains participate in forming the IL26 receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    text
  • blood coagulation
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL10 initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL10RA and IL10RB subunits
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine
    Susceptibility to diffuse cutaneous systemic sclerosis
    Variant & Polymorphism other
  • Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous systemic sclerosis
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS