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FLASH GENE

Symbol

IL10RB

contributors: mct - updated : 22-11-2012

HGNC name	interleukin 10 receptor, beta
HGNC id	5965

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q22.11      Physical location : 34.638.671 - 34.669.520
Synonym name	DNA segment, single copy (STS), probes pPW524-5P/7R, 771C6
Synonym symbol(s)	D21S58, D21S58E, CRFB4, IL10R2, CRF2-4, D21S66, CDW210B

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	30.87 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see IFNAR1

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Digestive intestine large intestine colon   moderately   intestine small intestine     moderately   pancreas exocrine       moderately   stomach       highly Lymphoid/Immune spleen       highly Reproductive female system placenta     moderately   female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two fibronectin type-III domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Il10rb
	homolog to chicken il10rb

Homologene

FAMILY

type II cytokine receptor family

CATEGORY

enzyme , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to membrane
	type I membrane protein

basic FUNCTION	acting as a receptor for IL10 and IL22
	serving as an accessory chain essential for the active IL10 receptor complex and to initiate IL10-induced signal transduction events
	IL20RA and IL10RB chains participate in forming the IL26 receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis , inflammation

text	blood coagulation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

IL10 initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL10RA and IL10RB subunits

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine

Susceptibility

to diffuse cutaneous systemic sclerosis

Variant & Polymorphism other	Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous systemic sclerosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS