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FLASH GENE
Symbol IL10RB contributors: mct - updated : 22-11-2012
HGNC name interleukin 10 receptor, beta
HGNC id 5965
Location 21q22.11      Physical location : 34.638.671 - 34.669.520
Synonym name DNA segment, single copy (STS), probes pPW524-5P/7R, 771C6
Synonym symbol(s) D21S58, D21S58E, CRFB4, IL10R2, CRF2-4, D21S66, CDW210B
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 30.87 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see IFNAR1
Physical map
C21orf119 21 chromosome 21 open reading frame 119 C21orf63 21q22.11 chromosome 21 open reading frame 63 C21orf77 21q22.11 chromosome 21 open reading frame 7 TCP10L 21q22.11 t-complex 10 (mouse)-like C21orf59 21q22.1 chromosome 21 open reading frame 59 LOC391279 21 similar to putative taste receptor HTR2 SYNJ1 21q22.1-q22.2 synaptojanin 1 C21orf66 21q22.11 chromosome 21 open reading frame 66 C21orf62 21q22.1 chromosome 21 open reading frame 62 OLIG2 21q22.11 oligodendrocyte lineage transcription factor 2 C21orf54 21q22.11 chromosome 21 open reading frame 54 IFNAR2 21q22.1 interferon (alpha, beta and omega) receptor 2 IL10RB 21q22.1-q22.2 interleukin 10 receptor, beta IFNAR1 21q22.1 interferon (alpha, beta and omega) receptor 1 IFNGR2 21q22.1 interferon gamma receptor 2 (interferon gamma transducer 1) C21orf4 21q22.1-q22.2 chromosome 21 open reading frame 4 RPS5L 21q22.11 ribosomal protein S5-like C21orf55 21q22.11 chromosome 21 open reading frame 55 GART 21q22.1 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase SON 21q22.1-q22.2 SON DNA binding protein DONSON 21q22.1 downstream neighbor of SON CRYZL1 21q22.1 crystallin, zeta (quinone reductase)-like 1 ITSN1 21q22.1-q22.2 intersectin 1 (SH3 domain protein) ATP5O 21q22.1-q22.2 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) LOC388819 21 similar to GNGT1 protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  moderately
 pancreas exocrine   moderately
 stomach   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemplacenta  moderately
 female systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type-III domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Il10rb
    homolog to chicken il10rb
    Homologene
    FAMILY
  • type II cytokine receptor family
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to membrane
  • type I membrane protein
  • basic FUNCTION
  • acting as a receptor for IL10 and IL22
  • serving as an accessory chain essential for the active IL10 receptor complex and to initiate IL10-induced signal transduction events
  • IL20RA and IL10RB chains participate in forming the IL26 receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    text
  • blood coagulation
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL10 initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL10RA and IL10RB subunits
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine
    Susceptibility to diffuse cutaneous systemic sclerosis
    Variant & Polymorphism other
  • Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous systemic sclerosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS