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FLASH GENE
Symbol ZNF746 contributors: mct - updated : 25-10-2011
HGNC name zinc finger protein 746
HGNC id 21948
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Kruppel-associated box (KRAB) at its N-terminus
  • a C2HC/C2H2 type zinc finger at its C terminus
    • HOMOLOGY
    Homologene
    FAMILY family of KRAB zinc-finger proteins (KRAB-ZFPs) transcriptional repressors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • KRAB and zinc finger protein that accumulates in Parkinson disease brain
  • physiological transcriptional repressor of PPRGC1A, which directly and endogenously occupies the cis-regulatory elements of PPRGC1A
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • represses the expression of the transcriptional coactivator PPARGC1A, by binding to insulin responsive sequences
  • parkin (PARK2) interacting substrate (parkin regulates the levels of PARIS via the ubiquitin proteasome system (UPS))
    • cell & other
    REGULATION
    Other regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    leads to the selective loss of Dopmaine neurons in the substantia nigra, and this is reversed by either parkin or PPARGC1A coexpression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS