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FLASH GENE

Symbol

ZNF746

contributors: mct - updated : 25-10-2011

HGNC name	zinc finger protein 746
HGNC id	21948

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152557 7 - 3813 - 644 - 2011 21376232 NM_001163474 7 - 3816 - 645 - 2011 21376232

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   lowly Homo sapiens   brain       highly Homo sapiens   brain midbrain substantia nigra   lowly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Kruppel-associated box (KRAB) at its N-terminus
	a C2HC/C2H2 type zinc finger at its C terminus

HOMOLOGY

Homologene

FAMILY

family of KRAB zinc-finger proteins (KRAB-ZFPs) transcriptional repressors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	KRAB and zinc finger protein that accumulates in Parkinson disease brain
	physiological transcriptional repressor of PPRGC1A, which directly and endogenously occupies the cis-regulatory elements of PPRGC1A

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	represses the expression of the transcriptional coactivator PPARGC1A, by binding to insulin responsive sequences
	parkin (PARK2) interacting substrate (parkin regulates the levels of PARIS via the ubiquitin proteasome system (UPS))

cell & other

REGULATION

Other

regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   leads to the selective loss of Dopmaine neurons in the substantia nigra, and this is reversed by either parkin or PPARGC1A coexpression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS