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FLASH GENE
Symbol TMEM57 contributors: mct - updated : 28-09-2011
HGNC name transmembrane protein 57
HGNC id 25572
Location 1p36.11      Physical location : 25.757.387 - 25.826.696
Synonym name
  • macoilin
  • Synonym symbol(s) RP3-469D22.2, FLJ10747, FLJ23007, MACOILIN, MACO-1
    DNA
    TYPE functioning gene
    STRUCTURE 69.31 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3940 - 664 - 2011 21437263
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    Nervousperipherous    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly conserved predicted transmembrane domains towards the N-terminus
  • coiled-coil regions C-terminal
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • localized mainly to the rough endoplasmic reticulum
  • basic FUNCTION
  • required for various neural events, such as the regulation of neuronal activity
  • required to evoke Ca2+ transients, at least in some neurons
  • involved in assembly or traffic of ion channels or ion channel regulators, but is not essential for transport of synaptic vesicles
  • acts in the ER to regulate assembly or traffic of ion channels or ion channel regulators
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS