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FLASH GENE
Symbol LYPD1 contributors: mct - updated : 21-09-2011
HGNC name LY6/PLAUR domain containing 1
HGNC id 28431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY Ly-6/neurotoxin superfamily
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
text expressed in postmitotic central and peripheral neurons
basic FUNCTION
  • may function in a new and TP53-independent tumor suppressor pathway
  • important component of the molecular mechanisms that control anxiety
  • membrane-tethered proteins LYNX1 and LYPD1 are co-localized with some CHRNA subtypes and modulate their activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can bind to and modulate neuronal nicotinic receptors, and loss of LYPD1 alters the actions of nicotine on glutamatergic signaling in the prefrontal cortex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors