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FLASH GENE

Symbol

LYPD1

contributors: mct - updated : 21-09-2011

HGNC name	LY6/PLAUR domain containing 1
HGNC id	28431

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001077427 3 - 1974 - 89 - 2006 16413018 NM_144586 3 - 2683 - 141 - 2006 16413018

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     highly Homo sapiens Nervous peripherous     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

Ly-6/neurotoxin superfamily

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
text	expressed in postmitotic central and peripheral neurons

basic FUNCTION	may function in a new and TP53-independent tumor suppressor pathway
	important component of the molecular mechanisms that control anxiety
	membrane-tethered proteins LYNX1 and LYPD1 are co-localized with some CHRNA subtypes and modulate their activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

can bind to and modulate neuronal nicotinic receptors, and loss of LYPD1 alters the actions of nicotine on glutamatergic signaling in the prefrontal cortex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors