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FLASH GENE
Symbol WDPCP contributors: mct - updated : 06-09-2011
HGNC name WD repeat containing planar cell polarity effector
HGNC id 28027
Corresponding disease
BBS15 Bardet-Biedl syndrome 15
Location 2p15      Physical location : -
Synonym name
  • Bardet-Biedl syndrome 15 protein
  • Synonym symbol(s) BBS15, C2orf86, DKFZp686C12204, FRITZ, FRTZ
    DNA
    TYPE functioning gene
    STRUCTURE 467.35 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3326 - 746 - 2010 20671153
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • WD40 repeats
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • acts potentially with septins to control both convergent extension and ciliogenesis
  • WDPCP and septins can collaborate during PCP-mediated collective cell movements
  • play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to the septin cytoskeleton in both ciliogenesis and collective cell movement
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BBS15
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS